李斯文,教授,博士研究生导师,国家优秀青年基金获得者,73882必赢网页版兴药领军学者。2020年江苏省青蓝工程优秀青年骨干教师,国家自然科学基金通讯评审专家,中国生物医学工程学会-生物光子学分会青年委员、江苏省生物医学工程学会副秘书长,江苏省药物研究与开发协会-医疗器械与药学装备专业委员会协会秘书、江苏省诊断试剂学会委员、多个SCI收录期刊审稿人。现任73882必赢网页版73882必赢网页版生物医学工程与诊断药学系支部书记。目前已主持纵向研究项目包括国家自然科学基金优秀青年项目、面上项目、青年项目、重大科研仪器研制项目(合作方负责人)以及江苏省自然科学基金-优秀青年基金项目、青年基金项目(结题优秀)等;主持荧光体外诊断试剂开发横向项目两项;专利技术“抗 HPV 光调制纳米微乳凝胶”等科技成果已在企业落地转化;参与国家基础研究计划(973 计划)及国家自然科学基金-重点项目等;获教育部高等学校科学研究优秀成果奖自然科学奖二等奖等奖项。
近年来,以第一或通讯作者身份在 Science Advances (IF=14.136),ACS Nano (IF=15.881), Advanced Science (IF=16.806), Biomaterials (IF=12.479), Chemical Engineering Journal (IF=13.273), Cancer Research (IF=12.701), Applied Materials Today (IF=10.041) 等国际权威期刊中发表 SCI 论文 19 篇(10 篇 IF>10)。研究成果被Nature Reviews Drug Discovery, Nature Reviews Materials, Chemical Society Reviews, Advanced Drug Delivery Reviews 等权威期刊及国家科技部官网等媒体亮点报道。申请专利 20项,获授权专利11 项。受邀在领域内国际学术会议做邀请报告 20 次以上。
2023-07 至今, 73882必赢网页版,73882必赢网页版,教授
2018-07 至 2023-07, 73882必赢网页版, 73882必赢网页版, 副教授
2015-07 至 2018-06, 73882必赢网页版, 73882必赢网页版, 讲师
2010-09 至 2015-06, 73882必赢网页版, 微生物与生化药学, 博士
2006-09 至 2010-06, 73882必赢网页版, 生物工程, 学士
研究方向:
1、基于干细胞囊泡的体内靶向治疗策略研究
2、体外诊断试剂开发及应用研究
3、功能性大健康产品开发研究
近五年代表性论文:
(1) Yuewen Zhai; Xiaorong He; Ying Li; Ran Han; Yuying Ma; Peng Gao; Zhiyu Qian; Yueqing Gu; Siwen Li ; A splenic-targeted versatile antigen courier: iPSC wrapped in coalescent erythrocyte-liposome as tumor nanovaccine, Science Advances, 2021, 7(35): eabi6326. (IF=14.136)
(2) Tian Xu; Yuying Ma; Qinling Yuan; Huixin Hu; Xinkai Hu; Zhiyu Qian; Janiqua Kyiesha Rolle; Yueqing Gu; Siwen Li ; Enhanced Ferroptosis by Oxygen-boosted Phototherapy Based on 2-in-1 Nano platform of Ferrous Hemoglobin for Tumor Synergistic Therapy, ACS Nano, 2020, 14(3): 3414-3425. (IF=15.881)
(3) Yuying Ma; Jinnan Zhang; Yalan Rui; Janiqua Rolle; Tian Xu; Zhiyu Qian; Yueqing Gu; Siwen Li ; Depletion of glioma stem cells by synergistic inhibition of mTOR and c-Myc with a biological camouflaged cascade brain-targeting nanosystem, Biomaterials, 2021, 268: 120564. (IF=12.479)
(4) Yuying Ma; Yanqin Zhang; Ran Han; Ying Li; Yuewen Zhai; Zhiyu Qian; Yueqing Gu; Siwen Li; A cascade synergetic strategy induced by photothermal effect based on platelet exosome nanoparticles for tumor therapy., Biomaterials, 2022, 282: 121384. (IF=12.479)
(5) Ying Li; Chunjiao Wu; Yuewen Zhai; Ran Han; Ruoyu Gu; Yuying Ma; Peng Gao; Zhiyu Qian; Yueqing Gu; Siwen Li ; Palliating the escalated post-PDT tumor hypoxia with a dual cascade oxygenation nanocomplex, Applied Materials Today, 2022, 26: 101287. (IF=10.041)
(6) Yuewen Zhai; Yuying Ma; Bo Pang; Jinnan Zhang; Ying Li; Yalan Rui; Tian Xu; Yu Zhao; Zhiyu Qian; Yueqing Gu; Siwen Li ; A cascade targeting strategy based on modified bacterial vesicles for enhancing cancer immunotherapy, Journal of Nanobiotechnology, 2021, 19(1): 434.(IF=10.435)
(7) Ping Li; Mengqiu Gao; Zijian Hu; Tian Xu; Jieru Chen; Yuxuan Ma; Siwen Li; Yueqing Gu ; Synergistic ferroptosis and macrophage re-polarization using engineering exosome-mimic M1 nanovesicles for cancer metastasis suppression, Chemical Engineering Journal, 2021, 409: 128217. (IF=13.273)
(8) Zhaohui Wang; Siwen Li; Min Zhang; Yi Ma; Yuxi Liu; Weidong Gao; Jiaqi Zhang; Yueqing Gu; Laser-Triggered Small Interfering RNA Releasing Gold Nanoshells against Heat Shock Protein for Sensitized Photothermal Therapy, Advanced Science, 2016, 4(2): 1600327. (IF=16.806)
(9) Jie Cao; Sisi Cui; Siwen Li; Changli Du; Junmei Tian; Shunan Wan; Zhiyu Qian; Yueqing Gu; Wei R Chen; Guangji Wang ; Targeted cancer therapy with a 2-deoxyglucose-based adriamycin complex, Cancer Research, 2013, 73(4): 1362-1373;(IF=12.701)
(10) Siwen Li; Yuxi Liu; Yalan Rui; Liping Tang; Samuel Achilefu; Yueqing Gu ; Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system, Theranostics, 2018, 8(10): 2621-2633;(IF=11.556)
联系方式:lsw@cpu.edu.cn